While ColonBroom contains psyllium husk, a natural fiber supplement known for aiding digestion, it is not a GLP-1 agonist. GLP-1 medications, such as semaglutide, are prescription drugs that mimic the GLP-1 hormone to regulate blood sugar and appetite. Some users have inquired about combining ColonBroom with GLP-1 medications, but it's essential to consult a healthcare professional before combining supplements with prescription medications.